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were outlined

Oxid Med Cell Longev 2021(1):6635460 Mathur A, Pandey VK, Kakkar P (2018) Activation of GSK3/-TrCP axis via PHLPP1 exacerbates Nrf2 degradation leading to impairment in cell survival pathway during diabetic nephropathy
Targeting glutamine metabolism and therapeutic implications Although the essential role of glutamine metabolism in cancer cells has been well demonstrated in vitro, the extent to which glutamine supports tumor growth and survival in vivo remains elusive

The fixed-effects model was first used for meta-analyses
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In addition to the decreased oxygen delivery, TME hypoxia can be further enhanced by high tumor oxygen consumption

based on statistical analyses carried out in the United States, 30% of new cases of it were recorded in 2021
