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Many patients do extremely well on the lower end when paired with a topical 2 %3 % serum and good sun protection

Using bacteriostatic water rather than sterile water extends shelf life after reconstitution due to the preservative (benzyl alcohol) that inhibits microbial growth
Caution is warranted because animal findings do not reliably map onto what happens in people

Intramuscular (IM) B12 Administration Protocol For those with vitamin B12 deficiency, intramuscular injections are a good treatment

So the evidence is there