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- The intervention was simple ( 1 cup of caffeinated coffee daily vs avoiding caffeine) and involved 200 participants randomized across multiple international sites

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Although Drp1-Ser637 phosphorylation predominantly suppresses mitochondrial fission under most physiological conditions, emerging evidence indicates its biological functions exhibit cell type-specific dependency and are dynamically regulated by microenvironmental signaling cues and upstream regulatory networks (Serasinghe and Chipuk, 2017)

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