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HUVECs grown on a stiffer gel of 10 kPa showed more VEGFR-2 endocytosis, a measure of activation, compared to HUVECs grown on a more compliant matrix of 1 kPa ( Hippo Pathway The Hippo pathway involves a kinase cascade leading to downstream transcription factors YAP and TAZ, which are involved in organ development as well as cell contractility, migration, and proliferation (225)

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Side effects at this dose are typically mild