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Cyanocobalamin is a cofactor for several enzymes which participate in crucial metabolic reactions, such as single carbon metabolism, cell growth and DNA synthesis

In receptor-targeted peptide systems, biological response can sometimes be interpreted relative to receptor binding or EC50 behavior

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Funding This work was funded in part by generous donations to WPLab, Inc., a non-profit corporation based in Durham, North Carolina

J Neurosci 29: 38163823

The study of pernicious anemia patients with relapse of anemia (Figure 10) (53) has shown that the depletion of serum vitamin B-12 after folic acid administration is accompanied by a proportional increase in reticulocyte counts, suggesting that serum vitamin B-12 is diverted into the hematopoietic system to provide the necessary vitamin B-12 coenzyme for methionine production