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It is known that the balance between pro- and anti-inflammatory cytokines produced in the liver determines the development of APAP hepatotoxicity (Fig

FXR and TGR5 are widely expressed in tissues and organs, including the liver, intestines, white adipose tissue, and heart

These cytokines bind to corresponding receptors on neurons, activating downstream signaling pathways such as NFB and MAPK [24]

From another point of view, there may be an opposite relationship between autophagy and lipolysis

Others, like tyrosine, support the production of brain chemicals that regulate alertness and motivation

Advances in single-cell omics and sequencing technologies have made it possible to uncover cellular and molecular signatures in health and disease in the brain that are distinct at the single cell level