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Strikingly, BCAAs metabolism displays paradoxical roles in diabetic pathophysiologygut dysbiosis-induced BCAA accumulation confers survival benefits in specific NSCLC-DM cohorts, yet effect directionality depends on individual metabotypes, necessitating longitudinal metabolomics to decode the DM-lung cancer risk continuum (Qian et al., 2022)

This glutamate elevation in synaptic strength results in heightened neuronal synchrony, leading to increased amplitude of brain electrical activity oscillations, potentially contributing to the generation of epilepticlike discharges in patients with GC1 deficiency

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Pedersen BK, Ostrowski K, Rohde T, Bruunsgaard H: The cytokine response to strenuous exercise

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