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Footnotes AUTHOR CONTRIBUTIONS: Young-Hoon Jung: Visualization, Writing original draft

When considering the potential metabolic pathways that lead to hyperhomocysteinemia it is important to note that the amino acid methionine, but not the amino acid cysteine, is the dietary precursor of homocysteine (Stipanuk et al, cited in Xiao et al, 2013)

23 Another study found that BPC-157 reduced post-surgical pain in an incisional wound model

But if budget allows, the methyl form is the better fit

While cyanocobalamin is a common synthetic form used in basic supplements, natural coenzyme forms like methylcobalamin and adenosylcobalamin are often preferred because the body can utilize them immediately for cellular energy and neurological support

Several small-molecule inhibitors of CYP51A1 have been developed, including clinically used azoles such as fluconazole and ketoconazole, which were originally designed to target fungal CYP51A1 but also inhibit the human enzyme (Table 3)