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The activation of MAPKs causes the phosphorylation of serine, threonine, and tyrosine residues of proteins to executive regulating function

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Initiation and progression of PD is dependent upon cellular events, including failures in the protein degradation machinery, oxidative stress, mitochondrial dysfunction, defects in mitochondrial autophagy (mitophagy) and the continuous accumulation of -synuclein, driven through cell to cell interactions between glial cells and neurons that ultimately lead to apoptosis [7,10,18]

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2020 Mar;9(Suppl 2):S149-S159

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Rateb EE, Amin SN, El-Tablawy N et al (2017) Effect of melatonin supplemented at the light or dark period on recovery of sciatic nerve injury in rats

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