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Elevations in the plasma levels of both cholesterol and triglycerides are seen in patients with increased plasma levels of IDL (Type III) and of LDL and VLDL (Type IIB) and in patients with increased levels of VLDL (Type IV)

[DOI] [PubMed] [Google Scholar] Tennison MB, Miles MV, Pollack GM, Thorn MD, Dupuis RE

PMC 2018708

While individual tolerance varies, stacking two compounds affecting liver metabolism and nutrient handling introduces unpredictable risksespecially muscle loss and nutrient depletion if combined with semaglutide's appetite suppression

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