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when this process is compromised, Fe + activates lipid peroxidases, producing reactive oxygen species (50), which oxidize membrane polyunsaturated fatty acids (PUFAs) to PUFA-OOHs, resulting in irreversible membrane damage and cellular apoptosis ( Figure 4 )

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reports personal fees for Data and Safety Monitoring Board activities (Nuvaira, Organicell) and consulting (Allergan/AbbVie) outside the published work

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Results vary based on individual factors including baseline cognitive function, lifestyle, adherence to protocol, and genetic factors

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