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Autosomal dominant iron overload due to a novel mutation of ferroportin1 associated with parenchymal iron loading and cirrhosis

Forward primers for mutagenesis were: R38A: CTC CGC GAC TGC ATT CCA GGC GCT AAC CAA CAA GGT TTT TG R130A: CCC TTC CTC AGC CAA ACG CGG GCT TGG CAT TTT TTG Mutants were expressed and activity measured in membrane fractions as described 47

Therefore, more in-depth studies are needed to elucidate the different effects of NADPH on ROS generation and other pathways involved in high glucose-induced ROS generation

Rahman, F

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