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Chronic treatment with tetrahydrobiopterin reverses endothelial dysfunction and oxidative stress in hypercholesterolaemia

10.1016/S1474-4422(03)00307-7 369 PierantozziM.PietroiustiA.SancesarioG.LunardiG.FedeleE.GiacominiP.et al

Discussion: The results indicate that animals exposed to HnB smoke show higher levels of oxidative stress markers, including those associated with DNA damage, as well as higher levels of pro-inflammatory cytokines

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This pulsatile action is key because it closely mimics the body's natural physiological rhythm

Glutathione is produced naturally by the liver and is also found in many foods
