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Studies in animal models show increased maximum lifespan, restored melatonin cycling, and improved neuroendocrine function in aged subjects

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However, challenges remain in optimizing their cartilage-specific targeting in dense ECM environments, understanding their effects on synovial and subchondral tissues, and validating long-term therapeutic benefits in age-related or metabolic OA models

So it would be advantageous to explore the possibilities of novel multi-target therapy, aimed to affect different disease-related mechanisms, resulting in additive or synergic therapeutic responses [7]

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