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The importance of GPx1 activity in the pathogenesis of protein-aggregation-induced cardiomyopathy was shown by the improvement of cardiac function and hypertrophy in HSP27 overexpressing mice treated with mercaptosuccinate to inhibit GPx1 activity

During the evolution of Cyanobacteria and Proteobacteria, GSH-dependent ROS detoxification systems incorporated enzymes that play crucial roles in these mechanisms and use GSH as a cofactor, such as GSH peroxidases, GSH reductases, glutaredoxins, and GSH-S-transferases [41]

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Results showed a 22 % increase in skin firmness and a 16 % reduction in fine lines measured by optical profilometry