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[DOI] [PubMed] [Google Scholar] 222.Nakamura H., Bai J., Nishinaka Y., Ueda S., Sasada T., Ohshio G., Imamura M., Takabayashi A., Yamaoka Y., Yodoi J

Genotoxicity of anticancer drug Azathioprine (Imuran): role of Omega-3 (-3) oil as protective agent

It is important to maintain a balanced and varied diet to ensure adequate intake of all essential nutrients, and to avoid excessive intake of potentially harmful substances

Supplementary material The Supplementary Material for this article can be found online at: Glossary ROS Reactive oxygen species RNS Reactive nitrogen species O 2 Superoxide anion radical H 2 O 2 Hydrogen peroxide OH Hydroxyl radicals 1 O 2 Singlet oxygen SOD Superoxide dismutase CAT Catalase GPx Glutathione peroxidase UA Uric acid GSH Glutathione ROO Peroxyl radical NO Nitric oxide NO 2 Nitrogen dioxide HOCl Hypochlorous acid HOBr Hypobromous acid O 3 Ozone HNO 2 Nitrous acid NO + nitrosyl cation NO Nitroxyl anion N 2 O 3 Dinitrogen trioxide N 2 O 4 Dinitrogen tetraoxide NO 2 + Nitronium (nitryl) cation ROOH Hydroperoxides HCOR Aldehydes OONO Peroxynitrite O 2 Molecular oxygen HO 2 Hydroperoxyl radical HOO Per hydroxyl radical NOS Nitric oxide synthases nNOS Neuronal NOS eNOS Endothelial NOS iNOS Inducible NOS NO 2 - Nitrite NO 3 - Nitrate CO 2 Carbon dioxide ONOOCO 2 Peroxo carboxylate ONOOH Peroxynitrous acid NO 2 + Nitrosonium cation HOCl Hypochlorous acid HOBr Hypobromous acid MPO Myeloperoxidase EPO Eosinophil peroxidase Q - Semiquinone anion NOX NADPH oxidase UVA Ultraviolet A 8-oxoGua 8-Oxo-7,8- dihydroguanine PFAS Per- and polyfluoroalkyl substances GST Glutathione-S-transferases GR Glutathione reductase BPA Bisphenol A BPAG Bisphenol A glucuronide BPAS Bisphenol A sulfate Dox Doxorubicin GSTP1 Glutathione S-transferase pi 1 HDCFDA 27-dichlorofluorescin diacetate HDCF 27-dichlorofluorescin DCF 2,7-dichlorofluorescein DHE Dihydroethidium 2-OH-E+ 2-hydroxyethidium E+ Ethidium cGMP cyclic guanosine monophosphate MAPK Mitogen-activated protein kinase PI3Ks Phosphoinositide 3-kinases PTEN Phosphatase and TENsin homolog Nrf2 Nuclear factor erythroid 2-related factor 2 Keap1 Kelch-like ECH-associated protein 1 NQO1 NAD(P)H quinone oxidoreductase 1 Srx1 Sulfiredoxin 1 PUFA Polyunsaturated fatty acids CH 2 Methylene group L lipid radical LOO Lipid peroxyl radical LA Linoleic acid AA Arachidonic acid EPA Eicosapentaenoic acid DHA Docosahexaenoic acid LOOH Lipid hydroperoxides H(P)ODEs Hydro(pero)xyoctadienoates MDA Malondialdehyde 4-HNE 4-Hydroxy-2-nonenal 4-HNE-MA 4-Hydroxynonenalmercapturic acid 4-ONE 4-Oxo-2-nonenal CML Carboxymethyl lysine PG Prostaglandin IsoPs Isoprostanes F2-IsoP F2-isoprostanes 8-isoPGF 2 8-isoprostaglandin F 2 11-PGF2 11--prostaglandin F2 15-PGF2 15-prostaglandin F2 8-OHdG 8-Hydroxy-2-deoxyguanosine 8-OHG 8-Hydroxyguanine 8-NO2-G 8-nitroguanine 8-oxoG 8-hydroxyguanosine or 7,8-dihydro-8-oxo-guanosine AD Alzheimers disease PD Parkinsons disease 8-NdG 8-nitroguanosine GSSG Glutathione disulfide AOPP Advanced Oxidation Protein Products AGEs Advanced glycation end products CoQ10 Coenzyme Q10 TRX Thioredoxins TRR Thioredoxin reductases PRX Thioredoxin peroxidases GRX Glutaredoxins TRX1 Thioredoxin-1 TRX2 Thioredoxin-2 CoQ10H 2 Ubiquinol ALA -Lipoic acid DHLA Dihydrolipoic acid NMN Nicotinamide mononucleotide ARE Antioxidant response element MMPs Metalloproteases SASP Senescence-associated secretory phenotype References 1 AhsanH