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Description
To that end, an E3 ligase activity-deficient mutant of UBR5 was generated by mutating the critical residue cysteine 2768 to alanine (UBR5C2768A, Mut-UBR5), as previously reported 39

The peptide mimetic DPP-4 inhibitors including vildagliptin, saxagliptin and teneligliptin, were identified by peptide-based substrate substitution experiments, while the non-peptide mimetic group such as sitagliptin, alogliptin and linagliptin, were derived from the inhibitor and initially found in random screening

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Despite these challenges, nutritional supplementation remains promising, particularly for patients seeking personalized or alternative therapies

Injections were considered
