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They were found to inhibit the ATPase activity of LptB

The protein/lipid ratio in the mitochondrial inner membrane is 3:1 thus upon tramadol exposure lipoxidative and protein oxidation damage can be induced by ROS (59, 60, 105, 106)

Biochim Biophys Acta Mol Basis Dis 1822:550556

NADPH oxidase mediates hypersomnolence and brain oxidative injury in a murine model of sleep apnea

doi: 10.1073/pnas.212507099
