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Surgery Surgical intervention remains appropriate for complete ruptures or severe cases that fail conservative management

Pickart and Margolinas 2018 review in Int J Mol Sci catalogs its regenerative and protective actions matrix remodeling, antioxidant and anti-inflammatory gene modulation, and wound-repair signaling but this is a review of largely preclinical and cell-based work (PMC6073405)

FDA-approved drugs have completed Phase I through Phase III clinical trials, received formal approval for specific indications, and carry standardized dosing and labeling

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The anti-inflammatory effects alone provide substantial relief