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Cancer cells are believed to behave in way that is metabolically different from normal, non-diseased cells

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Postulated mechanisms of metformin action, including AMPK activation and complex I inhibition, have been demonstrated in the setting of a consistent pleiotropic activity of this drug, suggesting that several molecular targets could be involved (LaMoia and Shulman, 2021)

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14 After escaping from endosomes, the next challenge is transporting NADs quickly and effectively to the nucleus or specific organelles