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Histone demethylase KDM3B protects against ferroptosis by upregulating SLC7A11

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While the connection of the Jak-STAT pathway to antiviral defense may be indirect because of its general involvement in tolerance to tissue damage by the activation of repair mechanisms (232), recent research in shrimp and hemipteran insects confirms a more complicated picture in which the Jak-STAT pathway may function directly in the detection of pathogens (including viruses) for the activation of anti-bacterial or antiviral effector genes (233, 234)

Notably, DAMPs and PAMPs act in a synergistic manner to trigger inflammatory responses during pathogenic infections

[DOI] [PMC free article] [PubMed] [Google Scholar] 27.Sekhar R.V., McKay S.V., Patel S.G., Guthikonda A.P., Reddy V.T., Balasubramanyam A., Jahoor F