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Description

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Briefly, the genomic DNA was extracted and the integrity of DNA was inspected using 1% agarose gel electrophoresis

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This creates interaction sites for FOXOs with phosphoserine-binding 14-3-3 proteins, resulting in their retention in the cytoplasm and decreased transcriptional activity in the nucleus [44, 45]

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methylglyoxal generates highly oxidative advanced glycation end products and can further induce oxidative stress and cause cell death (Uribarri et al., 2010)

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