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10.1007/s11064-006-9166-z 375 XuG.PattamattaA.HildagoR.PaceM

Patients and methods For this study, women patients with newly diagnosed Graves disease (n=18), treated with methimazole (n=6) and healthy subjects (n=15) were recruited

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A randomized, placebo-controlled study in 52 subjects (mean age, 30 years) with relapsing-remitting multiple sclerosis found an increase in total antioxidant capacity in blood with lipoic acid supplementation (1,200 mg/day for 12 weeks) yet not in the activity of specific antioxidant enzymes (superoxide dismutase and glutathione peroxidase) (97)

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However, after adding AG490, a specific inhibitor of JAK2, the signal transduction of the JAK2 pathway was inhibited, resulting in a significant decrease in the expression of STAT3 in the SW620 cell line