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Translating the Biology of Aging into New Therapeutics for Alzheimers Disease: Senolytics

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There is a large potential for variation in results according to the assay used, and support for the authenticity of a given assay is best generated by showing a correlation with an in vivo outcome

TAAR1 & Activation of NET/DAT/SERT Reverse Transport: Nature's Homeostatic Safety Valve Under baseline physiological conditions, catecholamines (like dopamine and norepinephrine) are kept sequestered at extremely low levels in the presynaptic cytoplasm (representing only ~3% of the total terminal contents), with the vast majority safely packaged in acidic storage vesicles (Hussain et al., 2023)

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Liu Q, Guan J, Song R, Zhang X, Mao S