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In addition, the hinokitiol copper complex (CuHK) has been confirmed as an inhibitor of the 19S DUB, but not the CT-like activity of the 20S proteasome (Chen et al., 2017)
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doi: 10.1007/s12011-021-02725-y, 151

Studies have found a decrease in antioxidant levels and an increase in oxidative damage products in patients with MDD, and have shown a positive correlation with the severity of the disease and the increased number of depressive episodes

10.1016/j.omtm.2019.11.017 [DOI] [PMC free article] [PubMed] [Google Scholar] 286.Borrs T, Buie LK, Spiga MG
