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Each factor contributes uniquely to the risk profile, and their interplay can exacerbate or mitigate injury risk (Figure 2)

It is characterized by diffuse thinning over the crown and frontal scalp, with preservation of the frontal hairline [36]

NAC, an effective antioxidant, has recently shown potent insulin-sensitizing effects in vitro [15, 16] and in animal models of obesity [39] and diabetes mellitus [40]

Similarly, our recent study demonstrated that rats with pre- or post-operative treatment of 275 mg/kg green tea extract (Theaphenon E) showed a higher RGC survival and axonal regeneration and improved pupillary light reflex post-optic nerve injury with the activation of Akt, Erk p42/44, and Stat3, as well as the downregulation of inflammation, apoptosis, and microglia activation genes, compared to the saline-treated rats [113]

LR3 enables interrogation of pathway dynamics across many hours to days

Chlorogenic Acid Ameliorates Colitis and Alters Colonic Microbiota in a Mouse Model of Dextran Sulfate Sodium-Induced Colitis