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Some people are more predisposed to getting PANS

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These structural insights support the idea that ITC side-chain structure critically influences GST binding affinity and may explain the observed differences in enzymatic activities and insect development

10.1111/j.1745-7254.2005.00161.x 46 LinX.-Y.CuiY.WangL.ChenW
The disease pathogenesis caused by the R216 mutation likely differs from that due to impaired FOG1 association, although the disease phenotypes partially overlap (7982)

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