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The antioxidant activity of phenolic acids in organisms is easily affected by environmental influences and often includes an oxidative effect under the action of Cu 2+

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Also, this pathway has cellular effects as silencing of the G6PD enzymethe first and rate-limiting enzyme of the PPP reduces EC proliferation and migration while increasing intracellular ROS (Leopold et al., 2003)

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Nrf2-associated markers of ferroptosis require binding to others for specific detection and detection of cellular ferroptosis