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& Wiseman, P

Aside from its detoxification role, it is important for a variety of essential cellular reactions

[DOI] [PubMed] [Google Scholar] 132.Hesta M., Ottermans C., Krammer-Lukas S., Zentek J., Hellweg P., Buyse J., Janssens G.P.J

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In EGF-stimulated CRC cells, fidarestat potentiated EGF-induced Nrf2 and upregulated the expression of peroxisome proliferator-activated receptor gamma coactivator (PGC)-1alpha, transcription factor A, mitochondrial (TFAM), and COX-IV and attenuated DNA damage as seen by decreased levels of 8-hydroxy-2'-deoxyguanosine