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Piroxicam, an oxidized drug, was cleared much more rapidly in cats than humans and dogs, although the mechanism for this difference is unclear
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Additionally, treatment of MCF-7 and MDA-MB-231 cells overexpressing CUL4B with the minimum effective dose of CSN5i-3 (4 M) significantly reduced the IC 50 of paclitaxel and docetaxel (Fig
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