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(1993) Metabolic effects of rhIGF-1 in normal human subjects

Strong evidence, from decades of treating individuals with inborn errors of B 12 metabolism, supports the safety of parenteral, lifelong, even high dose hydroxocobalamin, sometimes even at very high doses

J Biol Chem 290:89048912

But realistic expectations involve only modest weight loss

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1 Certain risk factors increase the prevalence of vitamin B 12 deficiency (Table 1)
