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Hypermelanotic pigmentation is a typical sign of overt disease and is seen in more than 70% of patients

Skin Pharmacol Physiol 27:4755 Rahimi R (2011) Creatine supplementation decreases oxidative DNA damage and lipid peroxidation induced by a single bout of resistance exercise

Kipp M, Clarner T, Dang J, Copray S, Beyer C

Emerging evidence indicates that reactivation of oncogenic signaling pathways is frequently accompanied by parallel reprogramming of metabolic networks, forming a coordinated dual-track mechanism of resistance driven by signaling-metabolism crosstalk [75]

After infusion, the IV line is removed, and patients can return to normal activities instantly