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Intrathecal administration of Org25935 and sarcosine (doses ranging from 3 to 300 ng for Org25935 and 20 to 300 ng for sarcosine) led to a significant increase in both mechanical and thermal pain thresholds in mice, with positive effects observed for up to 10 days post-administration

Commonly used for discrete pigmentation

This allows researchers to accurately assess the peptide's properties without confounding variables

doi: 10.1016/j.prostaglandins.2019.106363 34 ZhangH-LHuB-XLiZ-LDuTShanJ-LYeZ-Pet al

Targets the follicle, not just the surface

While there are advantages to standardizing a research definition in this way, there are also limitations to the application of this definition in the clinical setting, as there are multiple pathways through which patients who may be suffering from on-going symptoms from Lyme disease may not meet these narrow criteria