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Antagonists of the TLR4 receptor are also being sought that include synthetic lipid A analogues and the less toxic types from marine bacteria, extremophiles and the intestinal microbiome

Upon binding to these receptors, Melanotan 2 triggers a chain of biochemical events that ultimately lead to an increase in melanin production

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They include gastric lipase, colipase-dependent pancreatic lipase, pancreatic lipase-related proteins 2 (PLRP2), carboxyl ester hydrolase or bile salt-stimulated lipase (CEH, BSSL), and pancreatic phospholipase A2