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References Cuellar-Bermudez SP, Aguilar-Hernandez I, Cardenas-Chavez DL, Ornelas-Soto N, Romero-Ogawa MA, Parra-Saldivar R

This imbalance is further aggravated by hyperinflammation, mitochondrial dysfunction, and immune impairment commonly observed in these conditions [4,39]

This is consistent with the slower onset of action of morphine relative to heroin [72, 73, 214] and matches the anecdotal preference for heroin over morphine reported by opioid users [215]

For idiopathic hypersomnia, extended nighttime sleep and sleep inertia are commonly observed.104,105 Tunc et al conducted a study on 938 elderly outpatient patients and found that hypomagnesemia in the elderly is associated with excessive daytime sleepiness.11 Recent research has also revealed a positive correlation between the Magnesium Deficiency Score and excessive sleep, especially among non-depressed elderly individuals.12 An increase in SWS during compensatory stages 1 and 2, along with a shortening of REM sleep, contributes to increased excessive sleepiness in the elderly.106 Moreover, elderly individuals experiencing excessive sleepiness often exhibit impaired healthy eating habits, which may elevate the risk of malnutrition and consequently reduce magnesium intake.106 Thus, a bidirectional relationship may exist between magnesium deficiency and excessive sleepiness

372 Linderstrom-LangK

The Precision Peptide Genetic Test examines metabolic predispositionsincluding FTO rs9939609 and MC4R rs17782313that influence metabolic resilience and detoxification burden