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The relevance of this enzyme is illustrated by the fact that global SOD2 deficiency leads to neonatal death in mice (Huang et al., 1997)

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For example, in diabetic retinopathy (DR), SIRT1 suppresses inflammation and retinal vascular damage by regulating HMGB1 deacetylation and inhibiting ferroptosis (Peng et al., 2025)

Effect of NAC or L-NAC Pretreatment on the Secretion of Inflammatory Cytokines after PQ Challenge Levels of IL-8 secreted by cells exposed to 0.25 mM and 1.0 mM PQ were significantly increased relative to untreated control cells (Figure 5)

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81,82 Additionally, curcumin treatment has been reported to decrease global DNA methylation in a model of leukemia cells