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This review integrates current evidence on how brain peptides contribute to AD pathophysiology, summarizes recent progress in peptide-based therapeutic strategies and delivery platforms, and critically examines the remaining barriers to clinical translation, including bloodbrain barrier penetration, metabolic stability, off-target effects, and the need for biomarker-guided patient stratification

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Conversely, 19 metabolites, including HPV_PH enriched maltotriose and N-Acetyl-L-aspartic acid, negatively correlated with Lactobacillus