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Cell senescence: a nonnegligible cell state under survival stress in pathology of intervertebral disc degeneration

Given that cellular senescence is now recognized as one of the primary pillars of biological aging, this third mechanism elevates MOTS-c from a metabolic peptide to a potential geroscience intervention

Genetic deficiency of indoleamine 2, 3-dioxygenase promotes gut microbiota-mediated metabolic health

Any references to migration, angiogenesis, or tissue-related pathways are provided only for research context and do not imply therapeutic or clinical use

In preclinical research models, this interaction has been associated with changes in vascular tone and endothelial function parameters

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