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The majority involve the lateral ligament complex, particularly the anterior talofibular ligament (ATFL), which sustains damage in approximately 85% of inversion injuries

EVI/WLS function is regulated by ubiquitylation and is linked to ER-associated degradation by ERLIN2

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The von Hippel-Lindau tumor suppressor protein mediates ubiquitination of activated atypical protein kinase C

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