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[DOI] [PMC free article] [PubMed] [Google Scholar] 92.Zwaagstra JC, Ghiasi H, Slanina SM, Nesburn AB, Wheatley SC, Lillycrop K, et al

Simcox JA, McClain DA
Trimethyltin-induced differential expression of PAR subtypes in reactive astrocytes of the rat hippocampus
brain delivery thereof

Binding of IGF-1 to the IGF-1 receptor (IGF-1R) results in phosphatidylinositol-3-kinase (PI3K) activation, increasing phosphorylation of phosphatidylinositol-4,5-bisphosphate (PIP2) to generate phosphatidylinositol-3,4,5-trisphosphate (PIP3), which in turn results in the AKT and mTOR phosphorylation, as well as NFATc1 nuclear translocation, and subsequent transcription of genes related to cell survival and proliferation

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