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or i.g., without adverse effects was shown in mice, and a lethal dose (LD1) was not achieved, which also shows metabolites without harmful effect [3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21,22,23,24,27,28,29,30,31,32,34,37,39,40]

(2021) 118(25):e2104666118

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The study was approved by the Ethics Committee of Thomayer Hospital and the Institute of Clinical and Experimental Medicine, Prague, Czech Republic and carried out in accordance with the approved guidelines