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(2003) found that hypothyroidism caused oxidative stress in the liver and heart, causing an imbalance between ROS and endogenous antioxidant body defenses, with subsequent damage to cellular macromolecules ( L-thyroxine administration moderated such oxidative stress in hypothyroid rats through normalizing the plasma MDA level and plasma TAC, in agreement with Varghese et al

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Some drugs, including proton pump inhibitors, metformin, and contraceptives, may affect vitamin B12 levels

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Conceptually, the particular beneficial effect is that BPC 157 affects these disturbances when given peripherally
