5-amino-1mq nnmt inhibition mechanism Frontiers Emerging opportunities for nicotinamide N-methyltransferase

Association of nicotinamide-N-methyltransferase (NNMT) gene rs694539 variant with bipolar disorder

doi: 10.1172/jci.insight.90019

doi: 10.1093/eurheartj/ehn170

A compound that restores adipocyte metabolism without suppressing appetite could theoretically produce fat-specific weight loss that preserves lean mass a highly desirable outcome

In other words, the preclinical signal appears against a backdrop of controlled energy intake and activity, not as a standalone effect that overrides diet

14 Noticeably, a triple mutant (tm, K100A/E101A/E103A) of NNMT was designed to retain a comparable activity as the wild type NNMT, but reduce the entropy to facilitate its crystallization