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SOX9-COL9A3-dependent regulation of choroid plexus epithelial polarity governs blood-cerebrospinal fluid barrier integrity

But if that's the only step, recurrence is almost guaranteed

Glutamate can be generated by the amino-acid glutamine by the mitochondrial glutaminase (GLS)

Despite ROS production may not play a crucial role in aging, it is more likely to provoke aging via oxidative damage and interaction with mitochondria [18]

Oxidation of methionyl residues in proteins: tools, targets, and reversal
doi: 10.3233/JAD-130101
