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490 Fang found DOX increased Nrf2 nuclear accumulation, promoted the expression of HO-1, and caused heme degradation, and led to the rapid and systematic accumulation of free non-heme iron

IMQ-induced psoriatic mouse model Six-week-old female BALB/c mice or C57BL/6 mice, along with NRF2 knockout mice (acquired from the Model Animal Research Center of Nanjing University), were randomly grouped and maintained in an SPF environment, subjected to a 12-hour light/dark cycle, and provided with unrestricted access to food and water