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Therefore, it is necessary to understand how a variety of intrinsic and extrinsic factors are integrated to create the metabolic flexibility and to reduce the metabolic dependencies dictated by oncogenic signaling

(9) Lenzi A, et al

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In obesity, hypertrophic expansion of adipocytes leads to hypoxia, oxidative stress, and the release of pro-inflammatory adipokines, thereby promoting insulin resistance and ectopic lipid deposition [31]