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Differentiation of intestinal stem cells and enteroendocrine cells into L-cells The incretin hormone GLP-1 is one of the hormones that is produced by post-translational processing of proglucagon by proprotein convertase subtilisin-kexin type 1 (Pcsk1) or Pcsk3 in L-cells of the distal small bowel and colon

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Furthermore, GHSR1as constitutive activity has opened the door for investigation into the effects of inverse agonists, in particular [D-Arg 1 , D-Phe 5 , D-Trp 7,9 , Leu 11 ]-substance P (SP-analog), which has in turn provided hints to the structure and epitopes of the ghrelin receptor