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Inhibiting cholesterol esterification in T cells, either through genetic ablation or pharmacological inhibition of acetyl-coenzyme A acetyltransferases (ACAT1), a key cholesterol esterification enzyme, leads to increased levels of plasma membrane cholesterol levels, leading to potentiated effector function and enhanced proliferation of CD8+ T cells in melanoma and Lewis lung carcinoma models (85)

Stereoselective Synthesis of Novel Dipeptide -Turn Mimetics Targeting Melanocortin Peptide Receptors

JAMA Neurol (2015) 72(11):13745

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