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10.1212/01.wnl.0000166916.40902.63 100 JankovicJ

Sheppard M, Laskou F, Stapleton PP, Hadavi S, Dasgupta B

For instance, for the driver mutation-dependent subtype, a combined strategy of targeted therapy and epigenetic regulation should be adopted in accordance with molecular subtypes, such as the FGFR3-mutant subtype in bladder cancer

However, these agents have not yet been tested in clinical trials

This study provided a structural basis for the further engineering and application of TDC in the biocatalytic synthesis of tyramine

However, a recent in vitro study showed that crotalphin might reduce cell viability in primary neuronal cultures [210], which could restrict its clinical applicability