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demonstrated that a subset of PC9 lung cancer cells can adopt an NRF2-active program in response to osimertinib, a third-generation EGFR tyrosine kinase inhibitor, characterized by enhanced glutathione metabolism, antioxidative response, and a shift to fatty acid metabolism [56]

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Introduction Aging is a substantial risk factor for the development of inflammatory conditions, such as osteoarthritis (OA) and, probably, other degenerative, and neoplastic diseases of the bone, such as Paget disease of the bone and osteosarcoma ( Insulin/IGF1R Signaling Pathway The insulin/IGF-1 signaling system (IIS) is the route that regulates not only the organism's metabolism, but also the growth, development, and longevity concerning the availability status of nutrients

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